a tool for identifying drug-targetable redox-active disulphides

Early 35 kDa protein

Intermolecular

Cysteine 2 and cysteine 360 of Caspase-8 L

A redox-regulated disulphide may form between cysteine 2 of Early 35 kDa protein and cysteine 360 of Caspase-8 (2 and 2360 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

58

PDB code

Structure name

crystal structure of the caspase-8/p35 complex

Structure deposition date

2001-02-20

Thiol separation (Å)

6

Half-sphere exposure sum ?

nan

Minimum pK_a ?

10

% buried

84

Peptide A name

Early 35 kDa protein

Peptide B name

Caspase-8

Peptide A accession

Peptide B accession

Peptide A residue number

2

Peptide B residue number

360

Ligandability

Cysteine 2 of Early 35 kDa protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 360 of Caspase-8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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